Endocrine Abstracts

Introduction: There is no published data on dispensed drug pattern in patients with Autoimmune Addison’s disease (AAD). Sweden has excellent condition for research in this area, with high-quality population based registers. Among them is the Swedish Prescribed Drug Register (SPDR) that contains information about dispensed prescribed drugs. By linking registry data, we aimed at accurately estimate the prevalence and incidence of AAD, the prevalence of common concomitant au...

Similarly as in autoimmune Addison’s disease (AAD), diagnosed in about 80% of primary adrenal insufficiency, idiopathic isolated secondary adrenal insufficiency (ISAI) seems to have an autoimmune origin.Within the last 35 years we have registered in our Department 325 patients with ISAI (F/M ratio 10.9) aged 17–87 years. In comparison, we have in our registry 241 patients with AAD, collected within over 40 years. The diagnosis of ISAI was based...

Background: Conventional glucocorticoid replacement therapy is unphysiological, and does not restore quality-of-life in AD. Here we evaluated the dosing regimens and glucocorticoid metabolism in 10 patients undergoing 24 h sampling during oral replacement therapy and CSHI.Design, Subjects, Measurements: We set up a cross-over randomised multi-centre clinical trial to evaluate dosage and effects of CSHI in 40 Scandinavian AD patients, comparing 3 months o...